Composition of 2021-2022 Influenza Vaccine

Composition of 2021-2022 Influenza Vaccine

Pediatric/Adult Influenza Vaccine 2021-22 Cover ImageInfluenza Vaccine Composition for 2021-2022


Influenza vaccines expected to be available in the United States for the 2021–22 season will be quadrivalent vaccines. 

Egg-based Vaccines

  1. an A/Victoria/2570/2019 (H1N1)pdm09-like virus;
  2. an A/Cambodia/e0826360/2020 (H3N2)-like virus;
  3. a B/Washington/02/2019 (B/Victoria lineage)-like virus; and
  4. a B/Phuket/3073/2013 (B/Yamagata lineage)-like virus

Cell- or recombinant-based Vaccines

  1. an A/Wisconsin/588/2019 (H1N1)pdm09-like virus;
  2. an A/Cambodia/e0826360/2020 (H3N2)-like virus;
  3. a B/Washington/02/2019 (B/Victoria lineage)-like virus; and
  4. a B/Phuket/3073/2013 (B/Yamagata lineage)-like virus

List of currently available influenza vaccines in the U.S.

Influenza Vaccine Storage and Administration

IIV (Inactivated Influenza Vaccine) should be refrigerated at 2 degrees to 8 degrees C (36 degrees to 46 degrees F). Flu vaccine cannot be frozen. IIV should be administered in the deltoid muscle of older children and adults. The preferred injection site for infants and young children is the antero lateral aspect of the thigh. One inch needle lengths should be used for all groups, although large people may require immunization with a 1 ½ needle length.

Fluzone intradermal is administered intradermally via a single-dose, prefilled microinjection syringe. The preferred site for administration is over the deltoid muscle. Fluzone intradermal is indicated for persons aged 18 through 64 years.

LAIV (live attenuated influenza vaccine) is an option for influenza vaccination for 2021-2022 flu season.

Influenza Vaccine Clinic Resources

Flu Vaccine from ACPHD

Each year, we distribute flu vaccine to providers who agree to certain guidelines about to whom they will administer the vaccine and how and when to report usage. Visit our Flu Vaccine Distribution Program page for more information.


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